Meta-analysis of Diagnostic Accuracy Studies


The module on meta-analysis of diagnostic test studies

has been designed to teach you how to conduct a meta-analysis

study – from study design to manuscript preparation.

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About this course 

Diagnostic accuracy studies (DAS) are studies that involve a scientific assessment of the technical performance of a new test in the diagnosis of the target disease or condition. DAS are usually observational studies, and they are designed to address one of two broad goals:

Broad aim 1: To establish the diagnostic accuracy of the test for example in terms of Sensitivity and Specificity.

Broad aim 2: To evaluate the impact of the test strategy on therapy decisions and/or patient outcomes.

What will you learn

By the end of this course, the student should be able to:

      i.         Understand the concepts, meaning and importance of DAS.

     ii.         Develop a protocol for a meta-analysis study on DAS, including the ability to define the selection criteria for studies to be included in the meta-analysis.

   iii.         Carry out a comprehensive search of DAS on the selected test.

   iv.         Critique and assess the quality of study reports on diagnostic tests.

     v.         Manage the data i.e. define variablescollect data, and perform meta-analysis data analysis using applicable software, and interpret the findings.

   vi.         Prepare a manuscript on a meta-analysis study for publication.

  vii.         Discuss the limitations/biases and challenges faced with meta-analyses.


Last modified: Monday, 13 July 2015, 2:34 PM